The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time.

@article{Josefsson2013TheHR,
  title={The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time.},
  author={Lina Josefsson and Susanne von Stockenstrom and Nuno Rodrigues Faria and Elizabeth Sinclair and Peter Bacchetti and Maudi Killian and Lorrie Epling and Alice Tan and Terence Ho and Philippe Lemey and Wei Shao and Peter W. Hunt and Ma Somsouk and Will Wylie and Daniel C. Douek and Lisa Loeb and Jeff Custer and Rebecca A. Hoh and Lauren A Poole and Steven G. Deeks and Frederick M. Hecht and Sarah K. Palmer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 51},
  pages={E4987-96}
}
The source and dynamics of persistent HIV-1 during long-term combinational antiretroviral therapy (cART) are critical to understanding the barriers to curing HIV-1 infection. To address this issue, we isolated and genetically characterized HIV-1 DNA from naïve and memory T cells from peripheral blood and gut-associated lymphoid tissue (GALT) from eight patients after 4-12 y of suppressive cART. Our detailed analysis of these eight patients indicates that persistent HIV-1 in peripheral blood and… CONTINUE READING