The HIV-1 long terminal repeat contains an unusual element that induces the synthesis of short RNAs from various mRNA and snRNA promoters.

@article{Ratnasabapathy1990TheHL,
  title={The HIV-1 long terminal repeat contains an unusual element that induces the synthesis of short RNAs from various mRNA and snRNA promoters.},
  author={Ratneswaran Ratnasabapathy and Michael Sheldon and Lynn Johal and Nouria Hernandez},
  journal={Genes & development},
  year={1990},
  volume={4 12A},
  pages={2061-74}
}
We describe an unusual element that activates the synthesis of short transcripts from a wide variety of mRNA and small nuclear RNA (snRNA) promoters, including the U6 RNA polymerase III promoter. This inducer of short transcripts (IST) is located between positions -5 and +82 relative to the cap site in the HIV-1 LTR. In the presence of IST, the total transcriptional activity of the different promoters is greatly increased, but the resulting additional RNA molecules are short, ending around… CONTINUE READING