The HIV-1 integrase E157Q polymorphism per se does not alter susceptibility to raltegravir and dolutegravir in vitro.

@article{Saladini2017TheHI,
  title={The HIV-1 integrase E157Q polymorphism per se does not alter susceptibility to raltegravir and dolutegravir in vitro.},
  author={Francesco Saladini and Alessia Giannini and Adele Boccuto and Diletta Tiezzi and Ilaria Vicenti and Maurizio Zazzi},
  journal={AIDS},
  year={2017},
  volume={31 16},
  pages={
          2307-2309
        }
}
: The HIV-1 integrase E157Q natural polymorphism has been reported to cause one case of raltegravir (RAL) and dolutegravir (DTG) failure. Six recombinant viruses were constructed containing integrase from clinical HIV-1 isolates found to harbour E157Q as the only integrase strand inhibitor (INSTI) resistance-related mutation. Phenotypic analysis showed that E157Q results in minimal changes in RAL and DTG susceptibility. Together with data retrieved from the Stanford HIV database, our results… CONTINUE READING
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