The HIV-1 env protein: a coat of many colors.

@article{Arrildt2012TheHE,
  title={The HIV-1 env protein: a coat of many colors.},
  author={Kathryn Twigg Arrildt and Sarah Beth Joseph and R. Swanstrom},
  journal={Current HIV/AIDS reports},
  year={2012},
  volume={9 1},
  pages={52-63}
}
HIV-1 is completely dependent upon the Env protein to enter cells. The virus typically replicates in activated CD4+ T cells due to viral entry requirements for the CCR5 coreceptor and for high surface levels of the CD4 receptor. This is the case for the transmitted virus and for most of the virus sampled in the blood. Over the course of infection, the env gene can evolve to encode a protein with altered receptor and coreceptor usage allowing the virus to enter alternative host cells. In about… CONTINUE READING

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