The HIV-1 Integrase Mutations Y143C/R Are an Alternative Pathway for Resistance to Raltegravir and Impact the Enzyme Functions

@inproceedings{Reigadas2010TheHI,
  title={The HIV-1 Integrase Mutations Y143C/R Are an Alternative Pathway for Resistance to Raltegravir and Impact the Enzyme Functions},
  author={Sandrine Reigadas and Guerric Anies and Bernard Masquelier and Christina Calmels and Lieven J. Stuyver and Vincent Parissi and H{\'e}rv{\'e} Fleury and M L Andr{\'e}ola},
  booktitle={PloS one},
  year={2010}
}
Resistance to HIV-1 integrase (IN) inhibitor raltegravir (RAL), is encoded by mutations in the IN region of the pol gene. The emergence of the N155H mutation was replaced by a pattern including the Y143R/C/H mutations in three patients with anti-HIV treatment failure. Cloning analysis of the IN gene showed an independent selection of the mutations at loci 155 and 143. Characterization of the phenotypic evolution showed that the switch from N155H to Y143C/R was linked to an increase in… CONTINUE READING
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