The HIF-1-active microenvironment: an environmental target for cancer therapy.

  title={The HIF-1-active microenvironment: an environmental target for cancer therapy.},
  author={Shinae Kizaka-Kondoh and Shotaro Tanaka and Hiroshi Harada and Masahiro Hiraoka},
  journal={Advanced drug delivery reviews},
  volume={61 7-8},
Solid tumors possess unique microenvironments that are exposed to chronic hypoxic conditions, so-called tumor hypoxia. Although more than half a century has passed since it was suggested that tumor hypoxia correlated with bad treatment outcomes and contributed to the recurrence of cancer, no fundamental solution to this problem has yet been found. Hypoxia-inducible factor HIF-1 is the main transcription factor that regulates the cellular response to hypoxia. It induces various genes, whose… CONTINUE READING
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