The HGF/c-Met axis synergizes with G-CSF in the mobilization of hematopoietic stem/progenitor cells.

Abstract

As granulocyte-colony-stimulating factor (G-CSF)-induced mobilization of hematopoietic stem/progenitor cells (HSPCs) increases human serum levels of hepatocyte growth factor (HGF), our aim was to investigate the role of HGF and its receptor, c-Met, in the mobilization of HSPC. CD34(+) cells and leukocytes were isolated from the bone marrow (BM) of normal… (More)
DOI: 10.1089/scd.2009.0376

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