The HER family and cancer: emerging molecular mechanisms and therapeutic targets.

  title={The HER family and cancer: emerging molecular mechanisms and therapeutic targets.},
  author={Natalia V. Sergina and Mark M. Moasser},
  journal={Trends in molecular medicine},
  volume={13 12},
The human epidermal growth factor receptor (HER) family of transmembrane tyrosine kinases regulates diverse cellular functions in response to extracellular ligands. The deregulation of HER signaling through gene amplification or mutation is seen in many human tumors and an abundance of experimental evidence supports the etiological role of these events in cancer pathogenesis. In addition, the fact that they are feasible targets for both antibody and small-molecule therapeutics has made them… CONTINUE READING

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