The HER family and cancer: emerging molecular mechanisms and therapeutic targets.

@article{Sergina2007TheHF,
  title={The HER family and cancer: emerging molecular mechanisms and therapeutic targets.},
  author={Natalia V. Sergina and Mark M. Moasser},
  journal={Trends in molecular medicine},
  year={2007},
  volume={13 12},
  pages={527-34}
}
The human epidermal growth factor receptor (HER) family of transmembrane tyrosine kinases regulates diverse cellular functions in response to extracellular ligands. The deregulation of HER signaling through gene amplification or mutation is seen in many human tumors and an abundance of experimental evidence supports the etiological role of these events in cancer pathogenesis. In addition, the fact that they are feasible targets for both antibody and small-molecule therapeutics has made them… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 42 extracted citations

Safety and Pharmacokinetics/Pharmacodynamics of the First-in-Class Dual Action HER3/EGFR Antibody MEHD7945A in Locally Advanced or Metastatic Epithelial Tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2015
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…