The HECTD3 E3 ubiquitin ligase facilitates cancer cell survival by promoting K63-linked polyubiquitination of caspase-8

@inproceedings{Li2013TheHE,
  title={The HECTD3 E3 ubiquitin ligase facilitates cancer cell survival by promoting K63-linked polyubiquitination of caspase-8},
  author={Yong Li and Yanjie Kong and Zhe-Kun Zhou and Hongbin Chen and Zhengbo Wang and Y-C Hsieh and Dong Zhao and Xinglong Zhi and Jian Jhang Huang and Jiangyang Zhang and Hongmin Li and Ceshi Chen},
  booktitle={Cell Death and Disease},
  year={2013}
}
Apoptosis resistance is a hurdle for cancer treatment. HECTD3, a new E3 ubiquitin ligase, interacts with caspase-8 death effector domains and ubiquitinates caspase-8 with K63-linked polyubiquitin chains that do not target caspase-8 for degradation but decrease the caspase-8 activation. HECTD3 depletion can sensitize cancer cells to extrinsic apoptotic stimuli. In addition, HECTD3 inhibits TNF-related apoptosis-inducing ligand (TRAIL)-induced caspase-8 cleavage in an E3 ligase activity-dependent… CONTINUE READING