The HDL from septic-ARDS patients with composition changes exacerbates pulmonary endothelial dysfunction and acute lung injury induced by cecal ligation and puncture (CLP) in mice

@article{Yang2020TheHF,
  title={The HDL from septic-ARDS patients with composition changes exacerbates pulmonary endothelial dysfunction and acute lung injury induced by cecal ligation and puncture (CLP) in mice},
  author={Liu Yang and Sijie Liu and Silu Han and Yuhan Hu and Z. Wu and Xiaoqian Shi and Baosen Pang and Yingmin Ma and Jiawei Jin},
  journal={Respiratory Research},
  year={2020},
  volume={21}
}
Septic-acute respiratory distress syndrome (ARDS), characterized by the acute lung injury (ALI) secondary to aberrant systemic inflammatory response, has high morbidity and mortality. Despite increased understanding of ALI pathogenesis, the therapies to prevent lung dysfunction underlying systemic inflammatory disorder remain elusive. The high density lipoprotein (HDL) has critical protective effects in sepsis and its dysfunction has a manifested contribution to septic organ failure. However… Expand
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References

SHOWING 1-10 OF 42 REFERENCES
High-density lipoproteins during sepsis: from bench to bedside
TLDR
Clinical and experimental studies reinforce the potential of HDL therapy in human sepsis and detail the different effects of HDLs that may be relevant under inflammatory conditions and the lipoprotein changes during sepsi. Expand
The acute respiratory distress syndrome: pathogenesis and treatment.
TLDR
There is no effective pharmacologic therapy, although cell-based therapy and other therapies currently being tested in clinical trials may provide novel treatments for ARDS. Expand
Pulmonary coagulopathy as a new target in therapeutic studies of acute lung injury or pneumonia—A review
TLDR
Theoretical considerations suggest that this anticoagulant therapy will benefit patients with primary lung pathology including VILI, but clinical studies are needed to examine this hypothesis before such therapy is to be advocated as a standard of care in critically ill patients. Expand
Low HDL levels in sepsis versus trauma patients in intensive care unit
TLDR
Lipid profile was totally different between sepsis and trauma in ICU patients: HDL levels were low in septic patients, whereas their concentration was not altered in trauma patients, which reinforces the necessity to explore the therapeutic potential of HDL in sepsi. Expand
High-density lipoprotein (HDL) particle size and concentration changes in septic shock patients
TLDR
The results emphasize that HDL levels are dramatically decreased in the acute phase of septic shock and that there is a shift toward large HDL particles, which may reflect a major dysfunction of these lipoproteins. Expand
Regulators of endothelial and epithelial barrier integrity and function in acute lung injury.
TLDR
An overview of recently identified substances that inhibit and/or reverse endothelial barrier disruption and permeability or alveolar epithelial dysfunction is presented, which could contribute to the development of novel therapeutic strategies to combat permeability edema. Expand
Exploring the Predictive Ability of Dysfunctional High-Density Lipoprotein for Adverse Outcomes in Emergency Department Patients with Sepsis: A Preliminary Investigation
TLDR
Increasing Dys-HDL concentrations in the first 48 h of sepsis are associated with an ongoing inflammatory response and adverse clinical outcomes, and early changes in HII may be a potential biomarker in ED patients admitted withSepsis. Expand
Uremia alters HDL composition and function.
TLDR
The altered composition of HDL in renal disease seems to inhibit its cardioprotective properties, and this may help identify patients at increased risk for cardiovascular disease. Expand
Role of lung apolipoprotein A-I in idiopathic pulmonary fibrosis: antiinflammatory and antifibrotic effect on experimental lung injury and fibrosis.
TLDR
Alterations of several inflammatory and antiinflammatory proteins in the lungs may be related to the pathogenesis of IPF, and local treatment with Apo A-I is very effective against the development of experimental lung injury and fibrosis. Expand
The HDL proteome in acute coronary syndromes shifts to an inflammatory profile.
TLDR
Increased abundance of SAA, C3, and other inflammatory proteins in HDL from ACS patients suggests that HDL reflects a shift to an inflammatory profile which, in turn, might alter the protective effects of HDL on the atherosclerotic plaque. Expand
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