The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: Possible relevance for treatment-resistant depression.

@article{Meylan2016TheHI,
  title={The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: Possible relevance for treatment-resistant depression.},
  author={Elsa M. Meylan and Olivier Halfon and Pierre J. Magistretti and Jean-Ren{\'e} Cardinaux},
  journal={Neuropharmacology},
  year={2016},
  volume={107},
  pages={111-121}
}
Major depression is a highly complex disabling psychiatric disorder affecting millions of people worldwide. Despite the availability of several classes of antidepressants, a substantial percentage of patients are unresponsive to these medications. A better understanding of the neurobiology of depression and the mechanisms underlying antidepressant response… CONTINUE READING