The HDAC inhibitor LBH589 (panobinostat) is an inhibitory modulator of aromatase gene expression.

@article{Chen2010TheHI,
  title={The HDAC inhibitor LBH589 (panobinostat) is an inhibitory modulator of aromatase gene expression.},
  author={Shiuan Chen and Jingjing Ye and Ikuko Kijima and Dean Evans},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 24},
  pages={
          11032-7
        }
}
Aromatase converts androgens to estrogens. Although third-generation aromatase inhibitors (AIs) are important drugs in hormonal therapy for breast cancer in postmenopausal women, there are concerns about the side effects associated with the estrogen deprivation achieved with AIs. Expression of aromatase in breast cancer tissue is driven by different promoters than those in noncancer tissues; thus, suppression of aromatase expression in cancer tissues through the down-regulation of breast tumor… CONTINUE READING

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