The HCV core protein acts as a positive regulator of fas-mediated apoptosis in a human lymphoblastoid T cell line.


Hepatitis C virus (HCV) is a major human pathogen causing mild to severe liver disease worldwide and is remarkably efficient at establishing persistent infections. Previously, we have shown that the core protein has an immunomodulatory function including the suppression of T lymphocyte responses to viral infection. To investigate the underlying mechanism… (More)