The HB-6 , CDw 75 , and CD 76 Differentiation Antigens are Unique Cell-Surface Carbohydrate Determinants Generated by the ß-Galactoside a 2 , 6-Sialyltransferase

@inproceedings{Bast1992TheH,
  title={The HB-6 , CDw 75 , and CD 76 Differentiation Antigens are Unique Cell-Surface Carbohydrate Determinants Generated by the \ss-Galactoside a 2 , 6-Sialyltransferase},
  author={Bert E. J. E. G. Bast and L Zhou and Gordon J Freeman and Karen J Colley and Timothy J. Ernst and John M. H. Munro and Thomas F. Tedder},
  year={1992}
}
Expression of the ß-galactoside a2,6sialyltransferase (a2,6-ST) was shown to regulate the generation of multiple cell-surface differentiation antigens (Ags) that may be necessary for lymphocyte function . A new mAb was produced, termed HB-6, that was shown to identify a novel neuraminidasesensitive cell-surface Ag expressed by subpopulations of human lymphocytes and erythrocytes . In attempting to isolate a cDNA encoding the HB-6 antigen by expression cloning, a cDNA encoding the a2,6-ST (EC 2… CONTINUE READING
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