The H4IIE cell bioassay as an indicator of dioxin-like chemicals in wildlife and the environment.

@article{Whyte2004TheHC,
  title={The H4IIE cell bioassay as an indicator of dioxin-like chemicals in wildlife and the environment.},
  author={Jeffrey J. Whyte and Christopher J Schmitt and Donald E. Tillitt},
  journal={Critical reviews in toxicology},
  year={2004},
  volume={34 1},
  pages={
          1-83
        }
}
The H4IIE cell bioassay has proven utility as a screening tool for planar halogenated hydrocarbons (PHHs) and structurally similar chemicals accumulated in organisms from the wild. This bioassay has additional applications in hazard assessment of PHH exposed populations. In this review, the toxicological principles, current protocols, performance criteria, and field applications for the assay are described. The H4IIE cell bioassay has several advantages over the analytical measurement of PHHs… CONTINUE READING

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