The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia.

@article{Meulen2015TheHD,
  title={The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia.},
  author={J. C. van der Meulen and Viraj R. Sanghvi and Konstantinos J. Mavrakis and Kaat Durinck and Fang Fang and Filip Matthijssens and Pieter Rondou and Monica Rosen and Tim Pieters and Peter Vandenberghe and Eric C M Delabesse and Tim Lammens and Barbara de Moerloose and Bj{\"o}rn Menten and Nadine van Roy and Bruno Verhasselt and Bruce Poppe and Yves Benoit and Tom Taghon and Ari Melnick and Frank Speleman and Hans-Guido Wendel and Pieter Van Vlierberghe},
  journal={Blood},
  year={2015},
  volume={125 1},
  pages={13-21}
}
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive form of leukemia that is mainly diagnosed in children and shows a skewed gender distribution toward males. In this study, we report somatic loss-of-function mutations in the X-linked histone H3K27me3 demethylase ubiquitously transcribed X (UTX) chromosome, in human T-ALL. Interestingly, UTX mutations were exclusively present in male T-ALL patients and allelic expression analysis revealed that UTX escapes X-inactivation in female T-ALL… CONTINUE READING

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