The H19 lincRNA is a developmental reservoir of miR-675 which suppresses growth and Igf1r

@inproceedings{Keniry2012TheHL,
  title={The H19 lincRNA is a developmental reservoir of miR-675 which suppresses growth and Igf1r},
  author={Andrew Keniry and David Oxley and Paul Monnier and Michael Kyba and Luisa Dandolo and Guillaume Smits and Wolf Reik},
  booktitle={Nature Cell Biology},
  year={2012}
}
The H19 large intergenic non-coding RNA (lincRNA) is one of the most highly abundant and conserved transcripts in mammalian development, being expressed in both embryonic and extra-embryonic cell lineages, yet its physiological function is unknown. Here we show that miR-675, a microRNA (miRNA) embedded in H19’s first exon, is expressed exclusively in the placenta from the gestational time point when placental growth normally ceases, and placentas that lack H19 continue to grow. Overexpression… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 44 REFERENCES

Developmental adaptations to increased fetal nutrient demand in mouse genetic models of Igf2-mediated overgrowth.

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2011

Proteomic analysis of Sox2-associated proteins during early stages of mouse embryonic stem cell differentiation identifies Sox21 as a novel regulator of stem cell fate

Mallanna, K S.
  • Stem Cells
  • 2010

The H19 locus: role of an imprinted non-coding RNA in growth and development.

  • BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2010

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