The H1 receptor agonist 2-(3-chlorophenyl)histamine activates Gi proteins in HL-60 cells through a mechanism that is independent of known histamine receptor subtypes.

@article{Seifert1994TheHR,
  title={The H1 receptor agonist 2-(3-chlorophenyl)histamine activates Gi proteins in HL-60 cells through a mechanism that is independent of known histamine receptor subtypes.},
  author={Roland Seifert and Astrid Hagel{\"u}ken and Ariane H{\"o}er and D H{\"o}er and Lore Gr{\"u}nbaum and Stefan Offermanns and I Schwaner and V. Zingel and Walter Schunack and Guenter Schultz},
  journal={Molecular pharmacology},
  year={1994},
  volume={45 4},
  pages={578-86}
}
In dibutyryl-cAMP-differentiated HL-60 cells, histamine H1 and formyl peptide receptors mediate increases in the cytosolic Ca2+ concentration ([Ca2+]i) via pertussis toxin-sensitive G proteins of the Gi family. We compared the effects of 2-(3-chlorophenyl)-histamine (CPH) [2-[2-(3-chlorophenyl)-1H-imidazol-4-yl] ethanamine], one of the most potent and selective H1 receptor agonists presently available, with those of histamine and N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP) in these… CONTINUE READING

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