The H gene of rodent brain-adapted measles virus confers neurovirulence to the Edmonston vaccine strain.

@article{Duprex1999TheHG,
  title={The H gene of rodent brain-adapted measles virus confers neurovirulence to the Edmonston vaccine strain.},
  author={W Paul Duprex and I Duffy and Stephen McQuaid and Louise Hamill and S Louise Cosby and Martin A. Billeter and J{\"u}rgen Schneider-Schaulies and Volker ter Meulen and Bertus K Rima},
  journal={Journal of virology},
  year={1999},
  volume={73 8},
  pages={6916-22}
}
Molecular determinants of neuropathogenesis have been shown to be present in the hemagglutinin (H) protein of measles virus (MV). An H gene insertion vector has been generated from the Edmonston B vaccine full-length infectious clone of MV. Using this vector, it is possible to insert complete H open reading frames into the parental (Edtag) background. The H gene from a rodent brain-adapted MV strain (CAM/RB) was inserted into this vector, and a recombinant virus (EdtagCAMH) was rescued by using… CONTINUE READING

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