The H-2 phenotype of the thymus dictates the self-specificity expressed by thymic but not splenic cytotoxic T lymphocyte precursors in thymus-engrafted nude mice.

@article{Kruisbeek1981TheHP,
  title={The H-2 phenotype of the thymus dictates the self-specificity expressed by thymic but not splenic cytotoxic T lymphocyte precursors in thymus-engrafted nude mice.},
  author={Ada M. Kruisbeek and Susan O. Sharrow and Bonnie J. Mathieson and Alfred Singer},
  journal={Journal of immunology},
  year={1981},
  volume={127 5},
  pages={2168-76}
}
The present study was performed to examine the specificity of the self-recognition repertoire expressed by TNP-specific CTL precursors present in the thymus and the spleen of congenitally athymic nude mice engrafted with either semiallogeneic or fully allogeneic neonatal thymuses. It was shown that the engrafted thymus lobes were fully repopulated with cells of nude host origin and that the engrafted thymus tissue was capable of reconstituting peripheral CTL function in the nude host. Assessing… CONTINUE READING

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