The Gy mutation: another cause of X-linked hypophosphatemia in mouse.

@article{Lyon1986TheGM,
  title={The Gy mutation: another cause of X-linked hypophosphatemia in mouse.},
  author={Mary Frances Lyon and Charles R. Scriver and Laurence R. I. Baker and Harriet S. Tenenhouse and J C Kronick and S Mandla},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1986},
  volume={83 13},
  pages={
          4899-903
        }
}

• Mary Frances Lyon, Charles R. Scriver, +3 authors S Mandla
• Published 1986 in
  Proceedings of the National Academy of Sciences…

An X-linked dominant mutation (gyro, gene symbol Gy) in the laboratory mouse causes hypophosphatemia, rickets/osteomalacia, circling behavior, inner ear abnormalities, and sterility in males and a milder phenotype in females. Gy maps closely (crossover value 0.4-0.8%) to another X-linked gene (Hyp) that also causes hypophosphatemia in the mouse. Gy and Hyp genes have similar quantitative expression in serum phosphorus values, renal excretion of phosphate, and impairment of Na+/phosphate… CONTINUE READING

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