The GxxxG-containing transmembrane domain of the CCK4 oncogene does not encode preferential self-interactions.

@article{Kobus2005TheGT,
  title={The GxxxG-containing transmembrane domain of the CCK4 oncogene does not encode preferential self-interactions.},
  author={Felix J Kobus and Karen G Fleming},
  journal={Biochemistry},
  year={2005},
  volume={44 5},
  pages={1464-70}
}
The recently cloned colon carcinoma kinase 4 (CCK4) oncogene contains an evolutionarily conserved GxxxG motif in its single transmembrane domain (TMD). It has previously been suggested that this pairwise glycine motif may provide a strong driving force for transmembrane helix-helix interactions. Since CCK4 is thought to represent a new member of the receptor tyrosine kinase family, interactions between the TMDs may be important in receptor self-association and activation of signal transduction… CONTINUE READING

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