The Guanine Nucleotide-Binding Switch in Three Dimensions

@article{Vetter2001TheGN,
  title={The Guanine Nucleotide-Binding Switch in Three Dimensions},
  author={Ingrid R. Vetter and Alfred Wittinghofer},
  journal={Science},
  year={2001},
  volume={294},
  pages={1299 - 1304}
}
Guanine nucleotide–binding proteins regulate a variety of processes, including sensual perception, protein synthesis, various transport processes, and cell growth and differentiation. They act as molecular switches and timers that cycle between inactive guanosine diphosphate (GDP)–bound and active guanosine triphosphate (GTP)–bound states. Recent structural studies show that the switch apparatus itself is a conserved fundamental module but that its regulators and effectors are quite diverse in… Expand
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