The Great Mimicker: Metastatic Breast Carcinoma to the Head and Neck with Emphasis on Unusual Clinical and Pathologic Features

  title={The Great Mimicker: Metastatic Breast Carcinoma to the Head and Neck with Emphasis on Unusual Clinical and Pathologic Features},
  author={Dikson D. Gondim and Rebecca D. Chernock and Samir K. El-Mofty and James S. Jr. Lewis},
  journal={Head and Neck Pathology},
Distant metastases are relatively common in breast cancer, but spread to the head and neck region is uncommon and can be diagnostically challenging. Pathology databases of two academic hospitals were searched for patients. The diagnoses were by morphologic comparison with the primary breast specimen (when available) or through the use of immunohistochemical stains characteristic of breast carcinoma (cytokeratin 7, mammaglobin, GCDFP15, and/or GATA3 positive—excluding new primary tumors at the… Expand
Oral and maxillofacial metastasis of male breast cancer: Report of a rare case and literature review.
Clinicians should consider breast metastasis when evaluating reddish oral nodules in older patients, including men, especially those with a history of malignancy, after an 88-year-old male with previous history of a successfully treated primary breast adenocarcinoma was referred for evaluation of an oral swelling lasting 6 months. Expand
Lobular to Lobule: Metastatic Breast Carcinoma to Olfactory Neuroblastoma
Results confirmed TTM of an invasive lobular breast carcinoma to ONB, and a limited immunohistochemistry panel for all small round blue cell tumors that includes pancytokeratin, p40, S100 protein, SOX10, synaptophysin, desmin, CD99, and CD45 is employed. Expand
Metastatic Orbital Tumor From Breast Ductal Carcinoma With Neuroendocrine Differentiation Initially Presenting as Ocular Symptoms: A Case Report and Literature Review
A very rare case of cytokeratin 7 negative breast ductal carcinoma with neuroendocrine differentiation that metastasized to the orbit and formed a solitary giant tumor initially manifesting as ocular symptoms is described. Expand
Metastatic disease in head & neck oncology
  • P. Pisani, M. Airoldi, +34 authors Angelo Zigliani
  • Medicine
  • Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale
  • 2020
The aim of the present review is to provide an update on distant metastasis in head and neck oncology, with particular attention reserved to tumours with distant metastases and positive for EBV and HPV, and the oligometastatic concept. Expand
Rare sites of breast cancer metastasis: a review
It is uncommon to find isolated rare metastases, but the vast majority of these develops together with metastases in other sites, thus highlighting a worsening systemic disease. Expand
Solitary fibrous tumors of the head and neck region revisited: A single-institution study of 20 cases and review of the literature.
The results suggest that metastatic disease developed only in cases with STAT6 variants that included the DNA binding domain (STAT6--full variants), which contradicts expectations from previous reports and deserves further investigation. Expand
Orbital Metastases from Breast Cancer with BRCA2 Mutation: A Case Report and Literature Review
At the time of this publication, this is one of the first cases of BRCA2-associated breast cancer to present with orbital metastases, and the diagnostic challenges and literature regarding this rare presentation are discussed. Expand
Skull Base Metastasis of Breast Cancer With Oculomotor and Trochlear Nerve Palsy.
A 70-year-old woman presented with multiple cranial nerve palsy and endoscopic biopsy performed 5 years after the completion of breast cancer treatment revealed skull base metastases. Expand
Tumour-to-tumour metastasis: breast carcinoma to an olfactory neuroblastoma.
A 66-year-old woman with known breast cancer who presented with one-sided nasal symptoms and underwent endoscopic polypectomy is presented, demonstrating tumour-to-tumour metastasis from a breast carcinoma to an olfactory neuroblastoma, a rare sinonasal tumour. Expand


High frequency of lobular breast cancer in distant metastases to the orbit
Lobular breast cancer represents the cancer subtype with the highest prevalence among orbital metastases and illustrates the special metastatic behavior of this tumor entity and may have implications for the understanding of the organotropism of metastatic lobular breastcancer. Expand
Head and Neck Metastatic Tumors: a Retrospective Survey of Iranian Patients
The incidence rate of head and neck metastatic tumors seems to be low, however, feasible similarity of clinical presentation of oral metastatic lesions to benign lesions might result in misdiagnosis and biopsy is mandatory in any case with unusual clinical presentation, especially in patients with a known malignant disease. Expand
Metastatic tumours to the oral cavity - pathogenesis and analysis of 673 cases.
The clinical presentation of a metastatic lesion in the oral cavity can be deceiving leading to a misdiagnosis of a benign process, therefore, in any case where the clinical presentation is unusual especially in patients with a known malignant disease a biopsy is mandatory. Expand
Case report: Metastatic breast cancer presenting as a hypopharyngeal mass.
This report presents a case of a patient found to have a pedunculated mass in her right piriform sinus that would completely prolapse into the esophagus and cause symptoms, and represents the first case of metastatic breast carcinoma presenting as severe dysphagia. Expand
Metastatic tumours to the head and neck: retrospective analysis from a Brazilian tertiary referral centre.
Cervical lymph node metastases are a common event in patients with primary tumours growing elsewhere andRadiotherapy for the metastatic focus significantly prolonged the survival time of the patients (P=0.048). Expand
Cancer Metastatic to the Orbit: The 2000 Robert M. Curts Lecture
The most common primary cancers that metastasize to the orbit are breast, prostate gland, and lung cancer and the systemic prognosis is generally poor. Expand
Nonthyroid Metastasis to the Thyroid Gland
Surgical intervention is associated with improved survival, but expected morbidity of untreated tumors is difficult to assess, as site of origin, time to diagnosis, and surgical approach are related to survival and recurrence rates. Expand
Oral metastases: report of 24 cases.
Oral metastases are rare and may present at any age in both sexes and predominantly involve bony structures, particularly the mandible, in patients diagnosed with newly diagnosed oral cancers. Expand
Craniofacial metastases: a 20-year survey.
The long-term prognosis of 52 patients with distant metastases to the craniofacial area and possible predictive factors like age, gender, histopathological type of the metastasis, location and tissue structure of the area in the head and neck region, time between primary tumour and metastasis and the therapy were evaluated. Expand
Metastases to the oral mucosa: analysis of 157 cases.
  • A. Hirshberg, P. Leibovich, A. Buchner
  • Medicine
  • Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • 1993
A review of the English-language literature revealed 157 well-documented cases of metastatic lesions to the oral mucosa, most diagnosed in patients in their fifth to seventh decade, with the clinical appearance of the metastatic oral lesion resembled hyperplastic or reactive lesions. Expand