The Grasshopper: A Novel Model for Assessing Vertebrate Brain Uptake

@article{Andersson2013TheGA,
  title={The Grasshopper: A Novel Model for Assessing Vertebrate Brain Uptake},
  author={Olga Andersson and Steen Honor{\'e} Hansen and Karin Hellman and Line R{\o}rb{\ae}k Olsen and Gunnar Andersson and Lassina Badolo and Niels Svenstrup and Peter Aadal Nielsen},
  journal={The Journal of Pharmacology and Experimental Therapeutics},
  year={2013},
  volume={346},
  pages={211 - 218}
}
The aim of the present study was to develop a blood-brain barrier (BBB) permeability model that is applicable in the drug discovery phase. The BBB ensures proper neural function, but it restricts many drugs from entering the brain, and this complicates the development of new drugs against central nervous system diseases. Many in vitro models have been developed to predict BBB permeability, but the permeability characteristics of the human BBB are notoriously complex and hard to predict… 

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