The Grape Fruit Bioflavonoid Naringin Protects Against the Doxorubicin-Induced Micronuclei Formation in Mouse Bone Marrow

  title={The Grape Fruit Bioflavonoid Naringin Protects Against the Doxorubicin-Induced Micronuclei Formation in Mouse Bone Marrow},
  author={Ganesh Ch and R. Jagetia and T. K. Reddy},
Doxorubicin (DOX) is clinically used in the management of numerous neoplastic disorders however; development of life threatening cardiotoxicity and normal cytotoxicity is a major impediment in realizing its full potential in cancer therapy. The effect of various doses of Naringin was investigated on the DOX-induced DNA damage by micronucleus assay in mice bone marrow. Administration of mice with 5, 10 or 15 mg/kg body weight of DOX resulted in a dose dependent rise in the frequency of micro… Expand

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