The Gordon Wilson Lecture. Lessons about the control of glucose homeostasis and the pathogenesis of diabetes from knockout mice.

@article{Kahn2003TheGW,
  title={The Gordon Wilson Lecture. Lessons about the control of glucose homeostasis and the pathogenesis of diabetes from knockout mice.},
  author={C Ronald Kahn},
  journal={Transactions of the American Clinical and Climatological Association},
  year={2003},
  volume={114},
  pages={125-48}
}
  • C Ronald Kahn
  • Published 2003 in
    Transactions of the American Clinical and…
The painstaking process of generating constitutive and conditional knockout mice has paid off handsomely. The roles of the insulin receptor and its intracellular substrates in insulin action has been established and begun to shed light onto some of the proteins less obvious functions. We have learned how genetic predisposition plays itself out in the oligogenic and heterogeneous pathogenesis of type 2 diabetes and how the balance of proteins can affect the efficiency of signaling both… CONTINUE READING