The Goodpasture autoantigen. Structural delineation of two immunologically privileged epitopes on alpha3(IV) chain of type IV collagen.

@article{Kalluri1996TheGA,
  title={The Goodpasture autoantigen. Structural delineation of two immunologically privileged epitopes on alpha3(IV) chain of type IV collagen.},
  author={Raghuram Kalluri and Mae Jane Sun and Billy G Hudson and Eric G. Neilson},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 15},
  pages={
          9062-8
        }
}
The family of type IV collagen comprises six chains numbered alpha1 through alpha6. The alpha3(IV) NC1 domain is the primary target antigen for autoantibodies from patients with anti-basement membrane disease and Goodpasture syndrome. Earlier peptide studies suggested that the last 36 amino acids of the alpha3 NC1 domain probably contains one recognition site for Goodpasture autoantibodies, and an algorithm analysis of secondary structure from a later study predicted a second possible upstream… CONTINUE READING
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