The Golgi rapid method in clinical neuropathology: the morphologic consequences of suboptimal fixation.

@article{Williams1978TheGR,
  title={The Golgi rapid method in clinical neuropathology: the morphologic consequences of suboptimal fixation.},
  author={R. Sanders Williams and Robert Ferrante and Verne S. Caviness},
  journal={Journal of neuropathology and experimental neurology},
  year={1978},
  volume={37 1},
  pages={13-33}
}
Cytologic changes in neurons of the neocortex of mice consequent to suboptimal fixation have been investigated systematically in Golgi-rapid preparations. With few exceptions, there is no alteration in cellular morphology if the brain is refrigerated after death, and fixed by immersion within 3 hours. With latencies of fixation of 6 hours or more, autolytic changes supervene which modify the general histologic appearance and the morphology of individual cells. In general, the degree of tissue… CONTINUE READING

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