The Golgi-Associated Hook3 Protein Is a Member of a Novel Family of Microtubule-Binding Proteins

@article{Walenta2001TheGH,
  title={The Golgi-Associated Hook3 Protein Is a Member of a Novel Family of Microtubule-Binding Proteins},
  author={Jason H. Walenta and Aaron J. Didier and Xinran N Liu and Helmut Kr{\"a}mer},
  journal={The Journal of Cell Biology},
  year={2001},
  volume={152},
  pages={923 - 934}
}
Microtubules are central to the spatial organization of diverse membrane-trafficking systems. Here, we report that Hook proteins constitute a novel family of cytosolic coiled coil proteins that bind to organelles and to microtubules. The conserved NH(2)-terminal domains of Hook proteins mediate attachment to microtubules, whereas the more divergent COOH-terminal domains mediate the binding to organelles. Human Hook3 bound to Golgi membranes in vitro and was enriched in the cis-Golgi in vivo… CONTINUE READING

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