The GnRH antagonist reduces chemotherapy-induced ovarian damage in rats by suppressing the apoptosis.

@article{Huang2009TheGA,
  title={The GnRH antagonist reduces chemotherapy-induced ovarian damage in rats by suppressing the apoptosis.},
  author={Yan-hong Huang and Xue-jing Zhao and Qing-hong Zhang and Xiao-yan Xin},
  journal={Gynecologic oncology},
  year={2009},
  volume={112 2},
  pages={409-14}
}
OBJECTIVE GnRH antagonist cetrorelix could reserve the ovarian follicles during chemotherapy, but the mechanism remains unclear. The objectives of this study were to examine the overall effect of cetrorelix against ovarian failure and to define if the apoptotic process was involved. METHODS Female SD rats were injected with cetrorelix before and after administration of saline, or cyclophosphamide (Cy), or oral etoposide (VP). Main outcome measures were the number of ovarian follicles, serum… CONTINUE READING

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