The Gly972Arg polymorphism in the insulin receptor substrate-1 gene contributes to the variation in insulin secretion in normal glucose-tolerant humans.

@article{Stumvoll2001TheGP,
  title={The Gly972Arg polymorphism in the insulin receptor substrate-1 gene contributes to the variation in insulin secretion in normal glucose-tolerant humans.},
  author={Michael Stumvoll and Andreas Fritsche and Annette Volk and Norbert Stefan and Alexander Madaus and Elke Maerker and Anna Teigeler and Matthias Koch and Fausto Machicao and H G H{\"a}ring},
  journal={Diabetes},
  year={2001},
  volume={50 4},
  pages={882-5}
}
The Gly972Arg polymorphism in the insulin receptor substrate (IRS)-1 was found in some studies to have a higher prevalence in type 2 diabetic subjects than in control subjects. Previously, transfection of IRS-1 with this polymorphism into insulin-secreting cells resulted in a marked reduction of glucose-stimulated insulin secretion compared with the wild-type transfected cells. In the present study, we compared insulin secretion in well-matched normal glucose-tolerant subjects with and without… CONTINUE READING

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Defects of the insulin receptor substrate (IRS) system in human metabolic disorders.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2001
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Highly Influenced

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Amino acid polymorphism Gly 972 Arg in IRS-1 is not associated to lower clamp-derived insulin sensitivity in young healthy first degree relatives of patients with type 2 diabetes.

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