The Gly972-->Arg IRS-1 variant is associated with type 1 diabetes in continental Italy.

@article{Federici2003TheGI,
  title={The Gly972-->Arg IRS-1 variant is associated with type 1 diabetes in continental Italy.},
  author={Massimo Federici and Antonio Petrone and Ottavia Porzio and Carla Bizzarri and Davide Lauro and Rossella D'Alfonso and Ippolita Patrizia Patera and Marco Cappa and Lorenza Nistic{\'o} and Marco Baroni and Giorgio Sesti and Umberto Di Mario and Renato Lauro and Raffaella Buzzetti},
  journal={Diabetes},
  year={2003},
  volume={52 3},
  pages={887-90}
}
The Arg(972) insulin receptor substrate-1 (IRS-1) variant has been hypothesized to play a role in pancreatic beta-cell stimulus-coupled insulin secretion and survival. We analyzed the relations between type 1 diabetes and the Arg(972) IRS-1 variant. The frequency of the IRS-1 Arg(972) variant was investigated in two independent sets of unrelated patients: a case-control study and a collection of type 1 diabetes simplex families. In the former group, frequency of the IRS-1 Arg(972) variant was… CONTINUE READING