The Gluten-Free/Casein-Free Diet: A Double-Blind Challenge Trial in Children with Autism

@article{Hyman2016TheGD,
  title={The Gluten-Free/Casein-Free Diet: A Double-Blind Challenge Trial in Children with Autism},
  author={Susan L. Hyman and Patricia A. Stewart and Jennifer Foley and Usa Cain and Robin Peck and Danielle D. Morris and Hongyue Wang and Tristram H. Smith},
  journal={Journal of Autism and Developmental Disorders},
  year={2016},
  volume={46},
  pages={205-220}
}
Key MethodAbstract To obtain information on the safety and efficacy of the gluten-free/casein-free (GFCF) diet, we placed 14 children with autism, age 3–5 years, on the diet for 4–6 weeks and then conducted a double-blind, placebo-controlled challenge study for 12 weeks while continuing the diet, with a 12-week follow-up. Dietary challenges were delivered via weekly snacks that contained gluten, casein, gluten and casein, or placebo. With nutritional counseling, the diet was safe and well-tolerated…Expand
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References

SHOWING 1-10 OF 58 REFERENCES
The Gluten-Free, Casein-Free Diet In Autism: Results of A Preliminary Double Blind Clinical Trial
TLDR
Although preliminary, this study demonstrates how a controlled clinical trial of the GFCF diet can be conducted, and suggests directions for future research.
Effects of Gluten Free / Casein Free Diet in Young Children with Autism: A Pilot Study
TLDR
The results do not support use of a GFCF diet in ASD, and it is possible that a greater period of time is required for treatment before gains can be observed.
Gluten-free and casein-free diets in the treatment of autism spectrum disorders: a systematic review
TLDR
Critical analysis of each study's methodological rigor and results reveal that the current corpus of research does not support the use of GFCF diets in the treatment of ASD.
The ScanBrit randomised, controlled, single-blind study of a gluten- and casein-free dietary intervention for children with autism spectrum disorders
TLDR
The results suggest that dietary intervention may positively affect developmental outcome for some children diagnosed with ASD and is unable to disqualify potential effects derived from intervention outside of dietary changes.
A Gluten-Free Diet as an Intervention for Autism and Associated Spectrum Disorders: Preliminary Findings
The opioid-excess hypothesis of autism suggests that autism is the consequence of the incomplete breakdown and excessive absorption of peptides with opioid activity (derived from foods which contain…
Dietary Supplementation in Children with Autism Spectrum Disorders: Common, Insufficient, and Excessive.
Gluten- and casein-free diets for autistic spectrum disorder.
TLDR
To determine the efficacy of gluten- and/or casein- free diets as an intervention to improve behaviour, cognitive and social functioning in individuals with autism, a small number of randomised controlled trials are needed.
Double-blind, placebo-controlled food challenge (DBPCFC) as an office procedure: a manual.
Nutrient Intake From Food in Children With Autism
TLDR
Primary care for all children should include nutritional surveillance and attention to BMI, and children with ASD, like other children in America, consume less than the recommended amounts of certain nutrients from food.
A Randomised, Controlled Study of Dietary Intervention in Autistic Syndromes
TLDR
Evaluation of effect of gluten and casein-free diet for children with autistic syndromes and urinary peptide abnormalities found that the development for the group of children on diet was significantly better than for the controls.
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