The Glucagon-like Peptide-2 Receptor C Terminus Modulates β-Arrestin-2 Association but Is Dispensable for Ligand-induced Desensitization, Endocytosis, and G-protein-dependent Effector Activation*

@article{Estall2005TheGP,
  title={The Glucagon-like Peptide-2 Receptor C Terminus Modulates β-Arrestin-2 Association but Is Dispensable for Ligand-induced Desensitization, Endocytosis, and G-protein-dependent Effector Activation*},
  author={J. Estall and J. Koehler and B. Yusta and D. Drucker},
  journal={Journal of Biological Chemistry},
  year={2005},
  volume={280},
  pages={22124 - 22134}
}
  • J. Estall, J. Koehler, +1 author D. Drucker
  • Published 2005
  • Medicine, Biology
  • Journal of Biological Chemistry
  • Classic models of receptor desensitization and internalization have been largely based on the behavior of Family A G-protein-coupled receptors (GPCRs). The glucagon-like peptide-2 receptor (GLP-2R) is a member of the Family B glucagon-secretin GPCR family, which exhibit significant sequence and structural differences from the Family A receptors in their intracellular and extracellular domains. To identify structural motifs that regulate GLP-2R signaling and cell surface receptor expression, we… CONTINUE READING
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