The Glial Glutamate Transporter 1 (GLT1) Is Expressed by Pancreatic β-Cells and Prevents Glutamate-induced β-Cell Death*

@article{DiCairano2011TheGG,
  title={The Glial Glutamate Transporter 1 (GLT1) Is Expressed by Pancreatic $\beta$-Cells and Prevents Glutamate-induced $\beta$-Cell Death*},
  author={Eliana Sara Di Cairano and Alberto M. Davalli and Lucia Perego and Silvia Sala and Vellea Franca Sacchi and Stefano La Rosa and Giovanna Finzi and Claudia Placidi and Carlo Renato Capella and Paola Conti and Victoria E. Centonze and Francesca Casiraghi and Federico Bertuzzi and Franco Folli and Carla Perego},
  journal={The Journal of Biological Chemistry},
  year={2011},
  volume={286},
  pages={14007 - 14018}
}
Glutamate is the major excitatory neurotransmitter of the central nervous system (CNS) and may induce cytotoxicity through persistent activation of glutamate receptors and oxidative stress. Its extracellular concentration is maintained at physiological concentrations by high affinity glutamate transporters of the solute carrier 1 family (SLC1). Glutamate is also present in islet of Langerhans where it is secreted by the α-cells and acts as a signaling molecule to modulate hormone secretion… 

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