The Glial Glutamate Transporter 1 (GLT1) Is Expressed by Pancreatic β-Cells and Prevents Glutamate-induced β-Cell Death*

@article{Cairano2011TheGG,
  title={The Glial Glutamate Transporter 1 (GLT1) Is Expressed by Pancreatic $\beta$-Cells and Prevents Glutamate-induced $\beta$-Cell Death*},
  author={E. D. Di Cairano and A. Davalli and L. Perego and Silvia Sala and V. Sacchi and S. La Rosa and G. Finzi and C. Placidi and C. Capella and P. Conti and V. Centonze and F. Casiraghi and F. Bertuzzi and F. Folli and C. Perego},
  journal={The Journal of Biological Chemistry},
  year={2011},
  volume={286},
  pages={14007 - 14018}
}
Glutamate is the major excitatory neurotransmitter of the central nervous system (CNS) and may induce cytotoxicity through persistent activation of glutamate receptors and oxidative stress. Its extracellular concentration is maintained at physiological concentrations by high affinity glutamate transporters of the solute carrier 1 family (SLC1). Glutamate is also present in islet of Langerhans where it is secreted by the α-cells and acts as a signaling molecule to modulate hormone secretion… Expand
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Differential Expression of the Glutamate Transporter GLT-1 in Pancreas
  • J. Meabon, A. Lee, +7 authors D. Cook
  • Biology, Medicine
  • The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • 2012
TLDR
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