The Gla domain of factor IXa binds to factor VIIIa in the tenase complex.

@article{Blostein2003TheGD,
  title={The Gla domain of factor IXa binds to factor VIIIa in the tenase complex.},
  author={Mark D. Blostein and Barbara C. Furie and Isabelle Rajotte and Bruce Furie},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 33},
  pages={
          31297-302
        }
}
During blood coagulation factor IXa binds to factor VIIIa on phospholipid membranes to form an enzymatic complex, the tenase complex. To test whether there is a protein-protein contact site between the gamma-carboxyglutamic acid (Gla) domain of factor IXa and factor VIIIa, we demonstrated that an antibody to the Gla domain of factor IXa inhibited factor VIIIa-dependent factor IXa activity, suggesting an interaction of the factor IXa Gla domain with factor VIIIa. To study this interaction, we… CONTINUE READING

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