The Ginkgo biloba extract, EGb761, increases synaptosomal uptake of 5‐hydroxytryptamine: in‐vitro and ex‐vivo studies

@article{Ramassamy1992TheGB,
  title={The Ginkgo biloba extract, EGb761, increases synaptosomal uptake of 5‐hydroxytryptamine: in‐vitro and ex‐vivo studies},
  author={C. Ramassamy and Y. Christen and F. Clostre and J. Costentin},
  journal={Journal of Pharmacy and Pharmacology},
  year={1992},
  volume={44}
}
  • C. Ramassamy, Y. Christen, +1 author J. Costentin
  • Published 1992
  • Biology, Medicine
  • Journal of Pharmacy and Pharmacology
  • Abstract— The Ginkgo biloba extract (EGb 761) added to a synaptosomal fraction prepared from mice cerebral cortex modified [3H]5‐hydroxytryptamine ([3H]5‐HT) uptake in a biphasic manner. Between 4 and 16 μg mL−1 EGb 761 increased significantly the [3H]‐5‐HT uptake (maximum + 23%). A similar increase was also obtained when synaptosomes were prepared from the cortex of mice treated orally with EGb 761, either acutely (100 mg kg−1, 14 h and 2 h before death) or semi‐chronically (2× 100 mg−1 kg… CONTINUE READING
    48 Citations
    Decreased cerebral 5‐HT1A receptors during ageing: reversal by Ginkgo biloba extract (EGb 761)
    • 84
    Effect of the antioxidant action of Ginkgo biloba extract (EGb 761) on aging and oxidative stress
    • 44
    Ginkgo biloba neuroprotection: Therapeutic implications in Alzheimer's disease.
    • Y. Luo
    • Medicine
    • Journal of Alzheimer's disease : JAD
    • 2001
    • 60

    References

    SHOWING 1-10 OF 10 REFERENCES
    Prevention by a Ginkgo biloba Extract (GBE 761) of the Dopaminergic Neurotoxicity of MPTP
    • 49
    Protein measurement with the Folin phenol reagent.
    • 274,869
    A Multiple Comparison Procedure for Comparing Several Treatments with a Control
    • 5,377
    Ginkgo bilobaextract (EGb 761): pharmacological activities and clinical applications
    • 1991
    Effects of two platelet-activating factor antagonists, Bn 52063 and alprazolam, on forced swimming-induced behavioral despair in mice
    • Braquet P. (ed),
    • 1988
    Preparation et definition de l ' extrait de Ginkgo biloba ( EGb 761 )
    • Presse Medicale
    • 1986
    Protein measurement with the Fohn phenol reagent
    • J. Biol
    • 1951