• DOI:10.1111/j.2042-7158.1992.tb03244.x
Corpus ID: 25169001

The Ginkgo biloba extract, EGb761, increases synaptosomal uptake of 5‐hydroxytryptamine: in‐vitro and ex‐vivo studies

@article{Ramassamy1992TheGB,
  title={The Ginkgo biloba extract, EGb761, increases synaptosomal uptake of 5‐hydroxytryptamine: in‐vitro and ex‐vivo studies},
  author={C. Ramassamy and Y. Christen and F. Clostre and J. Costentin},
  journal={Journal of Pharmacy and Pharmacology},
  year={1992},
  volume={44}
}

C. Ramassamy, Y. Christen, +1 author J. Costentin

Published 1992

Biology, Medicine

Journal of Pharmacy and Pharmacology

Abstract— The Ginkgo biloba extract (EGb 761) added to a synaptosomal fraction prepared from mice cerebral cortex modified [3H]5‐hydroxytryptamine ([3H]5‐HT) uptake in a biphasic manner. Between 4 and 16 μg mL−1 EGb 761 increased significantly the [3H]‐5‐HT uptake (maximum + 23%). A similar increase was also obtained when synaptosomes were prepared from the cortex of mice treated orally with EGb 761, either acutely (100 mg kg−1, 14 h and 2 h before death) or semi‐chronically (2× 100 mg−1 kg… CONTINUE READING

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