The Genome of Chelonid Herpesvirus 5 Harbors Atypical Genes

  title={The Genome of Chelonid Herpesvirus 5 Harbors Atypical Genes},
  author={Mathias Ackermann and Maxim Y. Koriabine and Fabienne Hartmann-Fritsch and Pieter J de Jong and Teresa D. Lewis and Nelli Schetle and Thierry M Work and Julie Dagenais and George H. Balazs and J C Leong},
  booktitle={PloS one},
The Chelonid fibropapilloma-associated herpesvirus (CFPHV; ChHV5) is believed to be the causative agent of fibropapillomatosis (FP), a neoplastic disease of marine turtles. While clinical signs and pathology of FP are well known, research on ChHV5 has been impeded because no cell culture system for its propagation exists. We have cloned a BAC containing ChHV5 in pTARBAC2.1 and determined its nucleotide sequence. Accordingly, ChHV5 has a type D genome and its predominant gene order is typical… CONTINUE READING