The Genome of Borrelia recurrentis, the Agent of Deadly Louse-Borne Relapsing Fever, Is a Degraded Subset of Tick-Borne Borrelia duttonii

@article{Lescot2008TheGO,
  title={The Genome of Borrelia recurrentis, the Agent of Deadly Louse-Borne Relapsing Fever, Is a Degraded Subset of Tick-Borne Borrelia duttonii},
  author={Magali Lescot and St{\'e}phane Audic and Catherine Robert and Thi Diem Tien Nguyen and Guillaume Blanc and Sally J Cutler and Patrick Wincker and Arnaud Couloux and Jean-Michel Claverie and Didier Raoult and Michel Drancourt},
  journal={PLoS Genetics},
  year={2008},
  volume={4},
  pages={580 - 586}
}
In an effort to understand how a tick-borne pathogen adapts to the body louse, we sequenced and compared the genomes of the recurrent fever agents Borrelia recurrentis and B. duttonii. The 1,242,163-1,574,910-bp fragmented genomes of B. recurrentis and B. duttonii contain a unique 23-kb linear plasmid. This linear plasmid exhibits a large polyT track within the promoter region of an intact variable large protein gene and a telomere resolvase that is unique to Borrelia. The genome content is… CONTINUE READING