• DOI:10.1126/SCIENCE.1076181
Corpus ID: 4512225

The Genome Sequence of the Malaria Mosquito Anopheles gambiae

@article{Holt2002TheGS,
  title={The Genome Sequence of the Malaria Mosquito Anopheles gambiae},
  author={R. Holt and G. Subramanian and A. Halpern and G. Sutton and R. Charlab and D. Nusskern and P. Wincker and A. Clark and J. C. Ribeiro and R. Wides and S. Salzberg and B. Loftus and M. Yandell and William H. Majoros and D. Rusch and Z. Lai and C. Kraft and J. Abril and V{\'e}ronique Anthouard and P. Arensburger and P. Atkinson and H. Baden and V. de Berardinis and D. Baldwin and V. Bene{\vs} and J. Biedler and C. Blass and R. Bolanos and D. Boscus and M. Barnstead and S. Cai and A. Center and Kabir Chatuverdi and G. Christophides and M. A. Chrystal and M. Clamp and A. Cravchik and V. Curwen and A. Dana and A. Delcher and I. Dew and C. Evans and M. Flanigan and Anne Grundschober-Freimoser and L. Friedli and Z. Gu and P. Guan and R. Guig{\'o} and Maureen Hillenmeyer and S. L. Hladun and J. Hogan and Y. S. Hong and Jeffrey Hoover and O. Jaillon and Z. Ke and C. Kodira and E. Kokoza and A. Koutsos and I. Letunic and A. Levitsky and Y. Liang and Jhy-Jhu Lin and N. Lobo and J. Lopez and J. Malek and T. McIntosh and S. Meister and J. Miller and C. Mobarry and Emmanuel Mongin and Sean D. Murphy and D. O’brochta and Cynthia M Pfannkoch and R. Qi and Megan A. Regier and K. Remington and H. Shao and M. Sharakhova and Cynthia D. Sitter and J. Shetty and T. Smith and R. Strong and Jingtao Sun and D. Thomasova and L. Ton and P. Topalis and Z. Tu and M. Unger and B. Walenz and A. Wang and J. Wang and M. Wang and Xuelan Wang and K. Woodford and J. Wortman and M. Wu and A. Yao and E. Zdobnov and Hongyu Zhang and Q. Zhao and S. Zhao and S. C. Zhu and I. Zhimulev and M. Coluzzi and A. della Torre and C. Roth and C. Louis and F. Kalush and R. Mural and E. Myers and M. Adams and H. Smith and S. Broder and M. Gardner and C. Fraser and E. Birney and P. Bork and P. Brey and J. Venter and J. Weissenbach and F. Kafatos and F. Collins and S. Hoffman},
  journal={Science},
  year={2002},
  volume={298},
  pages={129 - 149}
}

• R. Holt, G. Subramanian, +120 authors S. Hoffman
• Published 2002
• Biology, Medicine
• Science

Anopheles gambiae is the principal vector of malaria, a disease that afflicts more than 500 million people and causes more than 1 million deaths each year. Tenfold shotgun sequence coverage was obtained from the PEST strain of A. gambiae and assembled into scaffolds that span 278 million base pairs. A total of 91% of the genome was organized in 303 scaffolds; the largest scaffold was 23.1 million base pairs. There was substantial genetic variation within this strain, and the apparent existence… Expand

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