The Genetics of Transcription Factor DNA Binding Variation

  title={The Genetics of Transcription Factor DNA Binding Variation},
  author={Bart Deplancke and Daniel Alpern and Vincent Gardeux},
Most complex trait-associated variants are located in non-coding regulatory regions of the genome, where they have been shown to disrupt transcription factor (TF)-DNA binding motifs. Variable TF-DNA interactions are therefore increasingly considered as key drivers of phenotypic variation. However, recent genome-wide studies revealed that the majority of variable TF-DNA binding events are not driven by sequence alterations in the motif of the studied TF. This observation implies that the… CONTINUE READING