The Genetics and Biology of Disc1—An Emerging Role in Psychosis and Cognition

@article{Porteous2006TheGA,
  title={The Genetics and Biology of Disc1—An Emerging Role in Psychosis and Cognition},
  author={D. Porteous and P. Thomson and N. Brandon and J. Millar},
  journal={Biological Psychiatry},
  year={2006},
  volume={60},
  pages={123-131}
}
In the developing field of biological psychiatry, DISC1 stands out by virtue of there being credible evidence, both genetic and biological, for a role in determining susceptibility to schizophrenia and related disorders. We highlight the methodologic paradigm that led to identification of DISC1 and review the supporting genetic and biological evidence. The original finding of DISC1 as a gene disrupted by a balanced translocation on chromosome 1q42 that segregates with schizophrenia, bipolar… Expand
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