The Genetic and Mechanistic Basis for Variation in Gene Regulation

  title={The Genetic and Mechanistic Basis for Variation in Gene Regulation},
  author={Athma A. Pai and Jonathan K. Pritchard and Yoav Gilad},
  booktitle={PLoS genetics},
It is now well established that noncoding regulatory variants play a central role in the genetics of common diseases and in evolution. However, until recently, we have known little about the mechanisms by which most regulatory variants act. For instance, what types of functional elements in DNA, RNA, or proteins are most often affected by regulatory variants? Which stages of gene regulation are typically altered? How can we predict which variants are most likely to impact regulation in a given… CONTINUE READING
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