The Genetic Structure of Ancient Human Populations

@article{Harpending1993TheGS,
  title={The Genetic Structure of Ancient Human Populations},
  author={Henry C. Harpending and Stephen T. Sherry and Alan R. Rogers and Mark Stoneking},
  journal={Current Anthropology},
  year={1993},
  volume={34},
  pages={483 - 496}
}
Ext. d'A.: In this paper we use a new method of analyzing mtDNA sequences that is based on a theory of how mismatch distributions -histograms of the number of pair-wise differences in the sample of DNA sequences- should preserve a record of population expansions and separations in the remote past 

Origin of Modern Humans: Interpreting the Molecular Evidence

Patterns of genetic diversity within our species imply that we descended from a small number of ancestors, of the order of several thousands. While early genetic evidence suggested major population

Population Structure and Modern Human Origins

This paper reviews statistical methods for inferring population history from mitochondrial mismatch distributions and extends them to the case of geographically structured populations. Inference is

Human mitochondrial DNA variation and the origin of Basques

The hypervariable segment I of the control region of the mtDNA (positions 16024–16383) was PCR‐amplified from mouth scrape and hairs and sequenced in 45 unrelated individuals of pure matrilineal

Humans: Demographic History

The genome of our species preserves a record of population dynamics – changes in size and of subdivision into partially isolated demes. Genetic data have revealed that our humans arose from a small

Modern human origins and prehistoric demography of Europe in light of the present-day genetic diversity.

The questions of the Neanderthal admixture as well as of the relative contribution of different waves of prehistoric migrations to the gene pool of modern Europeans are discussed.

Genetic evidence on modern human dispersals in South Asia: Y chromosome and mitochondrial DNA perspectives: The world through the eyes of two haploid genomes

Evidence of ancient human dispersals and settlement in South Asia is preserved in the genomes of its inhabitants, in the form of randomly accumulating mutations, which are passed down through the

Mitochondrial DNA variation and the origin of the Europeans

Estimated expansion times indicate a Paleolithic event with important differences among populations according to their geographical position and thus a slower tempo than previously believed and the replacement of Neanderthals by anatomically modern humans may have been a slower and more complex process than cultural change suggests.

Genetic traces of ancient demography.

This genetic evidence denies any version of the multiregional model of modern human origins and implies instead that the authors' ancestors were effectively a separate species for most of the Pleistocene.

The genetical history of humans and the great apes

The genetical history of humans and the great apes is studied to find out if there are any commonalities between modern humans and apes and other primates.

Using mitochondrial and nuclear DNA markers to reconstruct human evolution

These findings support a recent African origin of modern humans, but this conclusion should be tempered by the possible effects of factors such as gene flow, population size differences, and natural selection.
...

References

SHOWING 1-10 OF 18 REFERENCES

Mitochondrial DNA and human evolution

All these mitochondrial DMAs stem from one woman who is postulated to have lived about 200,000 years ago, probably in Africa, implying that each area was colonised repeatedly.

African populations and the evolution of human mitochondrial DNA.

The African origin hypothesis of human mtDNA evolution is supported by two statistical tests and two hypervariable segments of mtDNA were sequenced from 189 people of diverse geographic origin, including 121 native Africans.

Mitochondrial DNA sequences in single hairs from a southern African population.

Evidence of geographic structuring of the mitochondrial diversity in Africa, together with knowledge of the rate of accumulation of base changes in human mtDNA, implies that the average rate at which female lineages have moved their home bases during hunter-gatherer times could be as low as 13 meters per year.

Evolutionary relationships of human populations on a global scale.

A phylogenetic analysis of 26 representative populations from around the world by using the neighbor-joining (NJ) method has shown that the first major split of the phylogenetic tree separates Africans from non-Africans and that this split occurs with a 100% bootstrap probability.

Intraspecific nucleotide sequence differences in the major noncoding region of human mitochondrial DNA.

The phylogenetic analysis indicates that diversity among the negroids is much larger than that among the caucasoids or the mongoloids, and can be separated into two distinct groups in the Japanese.

New approaches to dating suggest a recent age for the human mtDNA ancestor.

Two approaches for deriving an intraspecific calibration of the rate of human mtDNA sequence evolution that allow standard errors to be readily calculated are presented.

Extensive mitochondrial diversity within a single Amerindian tribe.

Data do not support the concept of a dramatic founder effect during the peopling of the Americas and suggest that a single Amerindian tribe can contain such extensive molecular diversity, it is unnecessary to presume that substantial genetic bottlenecks occurred during the formation of contemporary ethnic groups.

Geographic variation in human mitochondrial DNA from Papua New Guinea.

Analysis of high resolution mitochondrial DNA restriction maps in Papua New Guinea shows that there is significant structuring of mtDNA variation among worldwide populations, between highland and coastal PNG populations, and even between two highland PNG populations located approximately 200 km apart; however, coastal PNG population are essentially panmictic, despite being spread over several hundred kilometers.

Average number of nucleotide differences in a sample from a single subpopulation: a test for population subdivision.

Using a Monte-Carlo simulation developed so that independent samples from a single subpopulation could be obtained quickly, this test is shown to be a useful method to determine if there is population subdivision.