The Genetic Determinants of Renal Impairment Following Cardiac Surgery

@article{Yates2006TheGD,
  title={The Genetic Determinants of Renal Impairment Following Cardiac Surgery},
  author={Robert B. Yates and Mark Stafford-Smith},
  journal={Seminars in Cardiothoracic and Vascular Anesthesia},
  year={2006},
  volume={10},
  pages={314 - 326}
}
Cardiac surgery is frequently performed, and acute renal dysfunction is a common adverse event following this procedure. Cardiac surgery-related renal injury independently predicts longer hospital stays and greater rates of morbidity and mortality. Although much work has been completed toward better understanding of this phenomenon, the state of knowledge concerning surgery-related renal injury remains limited. Currently, there is no effective paradigm to identify patients who are at risk for… 
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Cardiac surgery-associated acute kidney injury
TLDR
Strategies for reducing preoperative anemia, perioperative blood transfusions and surgical re-explorations may be effective in attenuating the incidence and severity of this complication.
Risk Factors for Acute Kidney Injury after-Cardiac Surgery
TLDR
Understanding of AKI, and renoprotection strategies related to cardiac surgery are discussed, and cardiopulmonary bypass does appear to adversely affect regulation of microvascular renal perfusion.
Acute kidney injury and chronic kidney disease after cardiac surgery.
TLDR
The confusing relationship (causal v epiphenomena) among acute kidney injury, chronic kidney disease, and adverse outcome after cardiac surgery; and an evidence-based assessment of the conduct of cardiac surgery and renoprotection strategies are evaluated.
Acute kidney injury following cardiac surgery: impact of early versus late haemofiltration on morbidity and mortality.
Emerging Concepts in Acute Kidney Injury Following Cardiac Surgery
TLDR
The focus will be on advances in risk stratification, evolving definitions and improving early diagnosis of AKI, identification of effective individualized therapies, and future directions.
Can postoperative renal dysfunction be predicted by measuring intraoperative glomerular filtration rate in patients undergoing coronary artery bypass grafting without cardiopulmonary bypass? A pilot study
TLDR
Postoperative renal dysfunction can be predicted from intraoperative glomerular filtration rate (GFR), and patients who have a rise in intraoperative GFR do not develop post operative renal dysfunction, and only patients with intraoperative fall in GFR are at risk of post surgical renal dysfunction.
Apolipoprotein E genotype, TNF-α 308G/A and risk for cardiac surgery associated-acute kidney injury in Caucasians
TLDR
Two common genetic polymorphisms that have previously been linked to renal failure and inflammation, and have been supposed to be associated with cardiac surgery associated-acute kidney injury (CSA-AKI), are not associated with renal injury after CPB.
Long‐term mortality associated with acute kidney injury in children following congenital cardiac surgery
TLDR
This work sought to determine the association between renal failure and longer‐term mortality in children following CCS.
Clinical Relevance of Pharmacokinetics and Pharmacodynamics in Cardiac Critical Care Patients
TLDR
In cardiac critical care patients, various pathophysiological conditions may significantly alter the pharmacokinetic behaviour of drugs, and the dosing regimens of several drugs are expected to be significantly different from those suggested for clinically stable patients.
‘Hardy’s Law’ and genomics in Anaesthesia
TLDR
The objective of this study was to demonstrate the power of simulation to improve the quality of the evaluation of aircrew performance in a real-time setting.
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References

SHOWING 1-10 OF 136 REFERENCES
Evidence-Based Renal Protection in Cardiac Surgery
  • M. Stafford-Smith
  • Medicine, Biology
    Seminars in cardiothoracic and vascular anesthesia
  • 2005
TLDR
Although numerous pharmacologic interventions to prevent or treat acute renal injury have shown promise in animal models, randomized placebo-controlled clinical trials that have looked at measures of significant adverse outcomes such as death and dialysis have not confirmed a benefit.
Association of genetic polymorphisms with risk of renal injury after coronary bypass graft surgery.
TLDR
It is identified that genetic polymorphisms that collectively provide 2- to 4-fold improvement over preoperative clinical factors alone in explaining post-cardiac surgery renal dysfunction are associated with increased renal inflammatory and/or vasoconstrictor responses.
Acute renal failure following cardiac surgery: incidence, outcomes and risk factors.
TLDR
It is confirmed that ARF following cardiac surgery is uncommon without pre-operative impairment of renal function but currently carries a mortality rate of 13%.
Acute renal failure following cardiac surgery.
  • P. Conlon, M. Stafford-Smith, +4 authors K. Landolfo
  • Medicine
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 1999
TLDR
The development of ARF or ARF-D is associated with a high mortality following CABG surgery and perioperative variables are identified, which may be useful in stratifying risk for the development ofARF.
Renal Dysfunction after Myocardial Revascularization: Risk Factors, Adverse Outcomes, and Hospital Resource Utilization
TLDR
The Multicenter Study for Perioperative Ischemia (McSPI) Research Group studied 2400 patients who underwent myocardial revascularization with cardiopulmonary bypass to determine the incidence and characteristics of postoperative renal dysfunction and failure, the predictors of renal dysfunction [determined by the use of multivariate modeling techniques], and the effect of kidney dysfunction on in-hospital resource utilization and patient disposition after discharge.
Mild renal failure is associated with adverse outcome after cardiac valve surgery.
Preliminary Report on the Association of Apolipoprotein E Polymorphisms, with Postoperative Peak Serum Creatinine Concentrations in Cardiac Surgical Patients
TLDR
Inheritance of the apolipoprotein E genotype &egr;4 allele is associated with reduced postoperative increase in serum creatinine after cardiac surgery, compared with the &EGr;3 or &egR;2 allele, the first report of a possible genetic basis for acute renal impairment.
Atherosclerosis of the ascending aorta is a predictor of renal dysfunction after cardiac operations.
Preoperative renal risk stratification.
TLDR
The risk of ARF after cardiac surgery can be accurately quantified on the basis of readily available preoperative data and may be used by physicians and surgeons to provide patients with improved risk estimates and to target high-risk subgroups for interventions aimed at reducing the risk and ameliorating the consequences of this serious complication.
A clinical score to predict acute renal failure after cardiac surgery.
TLDR
A score is valid and accurate in predicting ARF after open-heart surgery; along with increasing its clinical utility, the score can help in planning future clinical trials of ARF.
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