The Genetic Code Is One in a Million

@article{Freeland1998TheGC,
  title={The Genetic Code Is One in a Million},
  author={S. Freeland and L. Hurst},
  journal={Journal of Molecular Evolution},
  year={1998},
  volume={47},
  pages={238-248}
}
Abstract. [...] Key Result We find that if the bias affects all codon positions equally, as might be expected were the code adapted to a mutational environment with transition/transversion bias, then any reasonable transition/transversion bias increases the relative efficiency of the second base by an order of magnitude. In addition, if we employ weightings to allow for biases in translation, then only 1 in every million random alternative codes generated is more efficient than the natural code. We thus…Expand
The impact of including tRNA content on the optimality of the genetic code
On the efficiency of the genetic code after frameshift mutations
Codon Usage Decreases the Error Minimization Within the Genetic Code
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Load minimization of the genetic code: history does not explain the pattern
  • S. Freeland, L. Hurst
  • Computer Science
  • Proceedings of the Royal Society of London. Series B: Biological Sciences
  • 1998
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