The Gata1 5' region harbors distinct cis-regulatory modules that direct gene activation in erythroid cells and gene inactivation in HSCs.

@article{Takai2013TheG5,
  title={The Gata1 5' region harbors distinct cis-regulatory modules that direct gene activation in erythroid cells and gene inactivation in HSCs.},
  author={Jun Takai and Takashi Moriguchi and Mikiko Suzuki and Lei Yu and Kinuko Ohneda and Masayuki Yamamoto},
  journal={Blood},
  year={2013},
  volume={122 20},
  pages={3450-60}
}
GATA1 is a master regulator of hematopoietic differentiation, but Gata1 expression is inactivated in hematopoietic stem cells (HSCs). Using a bacterial artificial chromosome containing the Gata1 gene modified with green fluorescent protein (GFP) reporter, we explored the function of the 3.7-kb Gata1 upstream region (GdC region) that harbors 3 core cis-elements: Gata1 hematopoietic enhancer, double GATA-motif, and CACCC-motif. Transgenic GFP expression directed by the Gata1-BAC faithfully… CONTINUE READING
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