The Gastrointestinal Tract Metabolism and Pharmacological Activities of Grosvenorine, a Major and Characteristic Flavonoid in the Fruits of Siraitia grosvenorii

@article{Wang2015TheGT,
  title={The Gastrointestinal Tract Metabolism and Pharmacological Activities of Grosvenorine, a Major and Characteristic Flavonoid in the Fruits of Siraitia grosvenorii},
  author={Meng-yue Wang and Shihua Xing and Thi Xuyen Luu and Min Fan and Xiaobo Li},
  journal={Chemistry \& Biodiversity},
  year={2015},
  volume={12}
}
Grosvenorine is the major flavonoid compound of the fruits of Siraitia grosvenorii (Swingle) C. Jeffrey, a medical plant endemic to China. In the present study, for the first time, the grosvenorine metabolism in an in vitro simulated human gastrointestinal tract (including artificial gastric juice, artificial intestinal juice and intestinal flora), as well as its pharmacological activities (including anti‐complement, antibacterial and antioxidant activities), was investigated. The results… 
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References

SHOWING 1-10 OF 23 REFERENCES
Intestinal bacterial metabolism of flavonoids and its relation to some biological activities
TLDR
Anti-platelet activity and cytotoxicity of the metabolites of flavonoid glycosides by human intestinal bacteria were more effective than those of the parental compounds.
Chemistry and pharmacology of Siraitia grosvenorii: a review.
A new antibacterial compound from Luo Han Kuo fruit extract (Siraitia grosvenori)
Luo Han Kuo fruit (Siraitia grosvenori Swingle) has been used in China for centuries as a sweetening agent, and also used to treat sore throat and cough. In our recent study, a new bioactive…
Phytochemical and pharmacological aspects of Siraitia grosvenorii, luo han kuo
TLDR
Phytochemical research has shown that the fruit of this species is rich in triterpene glycosides that are very sweet, low in calories, and may be used as a substitute for sugar, and pharmacological results have shown that S. grosvenorii extracts and purified mogrosides exhibit antidiabetic, anticarcinogenic, antibacterial, antioxidant, and antiallergic effects.
Anticomplement and Antimicrobial Activities of Flavonoids from Entada phaseoloides
TLDR
The antimicrobial results indicated that quercetin, 5,7,4′-trihydroxy-3′-methoxyflavonol and galangin produced the inhibitory activities against MRSA, MSSA, and Standard Enterococcus, while luteolin and rhamnocitrin displayed inhibition against only MRSA and MSSA.
Antimicrobial activity of flavonoids
In vitro and in vivo antioxidant activity of aqueous extract from Choerospondias axillaris fruit
Flavonoids from the leaves of Litsea japonica and their anti‐complement activity
TLDR
Four flavonoids, epicatechin (1), afzelin (2), quercitrin (3), and tiliroside (4), were isolated from the leaves of Litsea japonica (Thunb.) Jussieu (Lauraceae) and showed the most potent inhibitory activity against the complement system.
Anti-complementary activity of flavonoids from Gnaphalium affine D. Don
Anti-complementary ginsenosides isolated from processed ginseng.
TLDR
The results suggest that the activity of the corresponding ginsenosides may be increased by the glycosyl moiety at the C₆ position rather than the double bond conformation at C ₂₀, and gINSenoside Rk₃ and Rh₄ could have a role in treating inflammatory diseases.
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