The Gamma-Aminobutyric Acidergic Effects of Valerian and Valerenic Acid on Rat Brainstem Neuronal Activity

  title={The Gamma-Aminobutyric Acidergic Effects of Valerian and Valerenic Acid on Rat Brainstem Neuronal Activity},
  author={Chun-Su Yuan and S. Mehendale and Ying-ping Xiao and H. Aung and J. Xie and M. Ang-Lee},
  journal={Anesthesia & Analgesia},
  • Chun-Su Yuan, S. Mehendale, +3 authors M. Ang-Lee
  • Published 2004
  • Biology, Medicine
  • Anesthesia & Analgesia
  • Valerian is a medicinal herb that produces anxiolytic and sedative effects. It was suggested that valerian acts via gamma-aminobutyric acid (GABA)ergic mechanisms. Previous studies showed binding of valerian extract to GABA receptors, but the functional effect of the binding has not been demonstrated. In this study we evaluated the GABAergic effect of valerian extract and one of its major constituents, valerenic acid, on brainstem neuronal activity in an in vitro neonatal rat brainstem… CONTINUE READING
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